Multi-modal recruitment of autophagy receptors amplifies mitophagy (#26)
Benjamin S Padman
1
,
Thanh N Nguyen
1
,
Louise Uoselis
1
,
Lan K Nguyen
1
,
Michael Lazarou
1
- Monash University, Clayton, VIC, Australia
Publish consent withheld
- (1) Lazarou, M., et al. 2015. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 524:309-14.
- (2) Nguyen, T.N., et al. 2016. Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. J Cell Biol. 215:857-74.
- (3) Wong, Y.C., et al. 2014. Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. Proc Natl Acad Sci U S A. 111:E4439-48.